Agno vs AutoGen
Agno and AutoGen are both agent frameworks for Python. Agno is published by Agno and AutoGen by Microsoft. On GitHub, AutoGen has 61,549 stars and Agno has 42,878. Both were last active in Oct 2026. The table lines up where they differ (publisher, license and weekly downloads) and has the install commands for both. Everything here comes from the listings' public sources and is refreshed daily. Agno describes itself as: Python framework and runtime for building agents, serving them over a REST API and MCP server, and managing them from a web control plane. AutoGen: Archived Microsoft Python framework for multi-agent apps; Microsoft directs new users to Microsoft Agent Framework. Licenses: Agno Apache-2.0, AutoGen CC-BY-4.0.
Updated Oct 26, 2026 · Built from catalog data; how we rank and grade
Agno
Agno
Python framework and runtime for building agents, serving them over a REST API and MCP server, and managing them from a web control plane.
AutoGen
Microsoft
Archived Microsoft Python framework for multi-agent apps; Microsoft directs new users to Microsoft Agent Framework.
Who should pick which
- Pick Agno if you want MCP support built in.
- Pick Agno if you want a stable release (AutoGen is marked experimental).
From listing data only. We don't pick a winner on security beyond the grades; read how grades work.
Side by side
| Fact | Agno | AutoGen |
|---|---|---|
| Type | Harness | Harness |
| Publisher | Agno | Microsoft |
| License | Apache-2.0 | CC-BY-4.0 |
| Pricing | Not stated | Not stated |
| Runs | Not stated | Not stated |
| Auth | Not stated | Not stated |
| Hosts supported | Not stated | Not stated |
| Tools | Not listed yet | Not listed yet |
| Security grade | –Security: not graded yet | –Security: not graded yet |
| Freshness grade | AFreshness: A | AFreshness: A |
| GitHub stars | 42,878 | 61,549 |
| Weekly downloads | 519,386 | 88,975 |
| Last release | Oct 23, 2026 | Sep 30, 2025 |
| Last activity | Oct 24, 2026 | Oct 16, 2026 |
Facts from each listing's public sources, checked daily. Tool lists arrive with tool scans.
Install
Agno
pip install agno
AutoGen
pip install autogen-agentchat
Also consider
- 0.853score
LlamaIndex
LlamaIndex
Open-source Python toolkit for RAG and agents over your own data, with event-driven workflows and 300+ integration packages.
HarnessAFreshness: A★ 52.6K↓ 1.4M/wk - 0.753score
LangChain
LangChain
Python framework of interoperable components and integrations for building agents and LLM apps, with LangGraph and Deep Agents layered above it.
HarnessAFreshness: A★ 148.4K↓ 37.3M/wk - 0.748score
LangGraph
LangChain
Low-level Python orchestration framework for long-running stateful agents, with durable execution, human review points and short- and long-term memory.
HarnessAFreshness: A★ 43.8K↓ 13.1M/wk
Questions
- Is Agno or AutoGen more popular?
- AutoGen has more GitHub stars (61,549 against 42,878). Stars measure attention, not quality, so check freshness and docs too.
- Are Agno and AutoGen open source?
- Yes: Agno is Apache-2.0 and AutoGen is CC-BY-4.0.
Related
Cite this page
Agno vs AutoGen. Agent Mart. https://agentmart.dev/compare/agno-vs-autogen (last updated 2026-10-26)