gene-lookup

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• SKILL.md

SKILL.md (first lines)

# Gene Lookup

Query standard gene databases for nomenclature, function, variants, and disease associations.

## Commands

| Command | Description |
|---------|-------------|
| `web_search "site:genenames.org <gene-symbol>"` | HGNC approved name and aliases |
| `web_search "site:omim.org <gene-symbol>"` | OMIM gene-disease associations |
| `web_search "site:ncbi.nlm.nih.gov/clinvar <gene-symbol>"` | ClinVar variants |
| `web_search "site:uniprot.org <gene-symbol>"` | UniProt protein information |
| `web_search "site:gtexportal.org <gene-symbol>"` | GTEx expression data |

## Output

For each gene, compile:
- HGNC symbol, full name, aliases
- Chromosomal location
- OMIM phenotype associations
- ClinVar pathogenic variants (count, top variants)
- UniProt ID, protein family, domains
- Expression profile (tissue-specific)
- Known drugs targeting this gene product

Save to `outputs/gene-lookup-<slug>.md`.

From yejunbin/darwin, MIT.

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