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Mosaic Pre-Clinical Intelligence

Pre-clinical drug-target intelligence: 60 curated targets, 1,969 counted partner genes, 11 tools

Connector by sourabhnk · GitHub account verified by the MCP Registry

IndexedApache-2.0Local (stdio)
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Works with Claude Code, Codex, VS Code, Cursor, Windsurf, Claude Desktop. Read the repository before you give any tool access to your data.

npx agentmarket install connector/sourabhnk-mosaic-mcp

Asks which of your tools to add it to (Claude Code, Codex, Cursor, VS Code, Windsurf, Gemini CLI, Claude Desktop) and shows the change first. See https://agentmart.dev/cli.

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About

Pre-clinical drug-target intelligence: 60 curated targets, 1,969 counted partner genes, 11 tools

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Permissions

What this server can do and what it asks for, from its tool list, install config and code. Checked Oct 25, 2026.

Tools
11 read · 0 write · 0 deleteRead-only
Secrets
2 (API keys, tokens or passwords)
Install scripts
None found
Runs as
Python package

Tools by what they do 11

Read from the source code; the running server may list different tools.

Read 11 · Look things up without changing anything.

  • mosaic_clinical_pipeline
  • mosaic_get_coverage_grid
  • mosaic_get_target_compounds
  • mosaic_get_target_papers
  • mosaic_get_target_profile
  • mosaic_get_target_structure
  • mosaic_pathway_context
  • mosaic_resistance_bypass_map
  • mosaic_synthetic_lethal_whitespace
  • mosaic_target_network
  • mosaic_target_validation

Secrets and settings it asks for

Secrets: values you paste in that let it act as you.

  • DATABASE_URL
  • MOSAIC_API_KEY

Other settings (environment variables or headers).

  • MOSAIC_TIER

Network hosts it talks to 8

  • alphafold.ebi.ac.uk · found in code
  • getmosaic.dev · found in code
  • github.com · found in code
  • glama.ai · found in code
  • mcp.getmosaic.dev · found in code
  • pubmed.ncbi.nlm.nih.gov · found in code
  • rest.genenames.org · found in code
  • uniprot.org · found in code

Tools (11)

Read from the source code; the running server may differ. Descriptions are the server’s own words; hidden characters are shown as [U+…].

  • mosaic_clinical_pipelineClinical Trial Pipelineread-only

    Get clinical trial pipeline for compounds targeting a gene. Returns compounds in clinical development with indications, trial phases, and status from ClinicalTrials.gov data.

  • mosaic_get_coverage_gridCoverage Grid (any human target)read-only

    Coverage-honest grid for ANY human gene symbol - the live demo of the mechanism. In this self-hosted package the grid resolves identity (HGNC) and structure (AlphaFold DB) live; the remaining axes are marked `queued` and are computed by the hosted service's dossier pipeline (getmosaic.dev). Every count carries a state; nothing unfetched is a zero.

  • mosaic_get_target_compoundsGet Target Compoundsread-only

    Get compounds active against a specific drug target. Returns compounds with activity data (IC50, Ki, etc.), sorted by potency or, with sort='max_phase', approved and clinical drugs first. Unnamed research compounds read compound_name 'unnamed' with the ChEMBL id in chembl_id.

  • mosaic_get_target_papersGet Target Papersread-only

    Get scientific papers about a specific drug target. Where the database carries PubTator3 gene annotations, only papers tagged with the target's NCBI Gene ID are served (`membership_basis` says which test applied), dated by the earliest of e-pub / issue / PubMed entry, papers naming the target in the title first.

  • mosaic_get_target_profileGet Target Profileread-only

    Get a comprehensive intelligence dossier for a drug target. Returns UniProt biology, target scores, SAR summary, disease associations, validation evidence, pathways, PPIs, competitive landscape, clinical pipeline, and publication momentum. This is the primary tool for any target question.

  • mosaic_get_target_structureGet Target Structure (AlphaFold)read-only

    Get the AlphaFold structural snapshot for a drug target. Returns AlphaFold model URLs (PDB / CIF / PAE), per-residue confidence summary (mean pLDDT, fractions of residues at high / confident / low confidence, disordered fraction), and protein length. Useful for SBDD scoping, disorder/IDR risk, and confidence-aware target triage. Also returns the fpocket pockets with both rankings (fpocket score and Druggability Score), which one selected the top pocket, and the pLDDT of the residues lining each pocket.

  • mosaic_pathway_contextPathway Contextread-only

    Get pathway context for a drug target. Shows which biological pathways the target participates in, other targets in the same pathways, and protein-protein interactions.

  • mosaic_resistance_bypass_mapResistance Bypass Mapread-only

    Candidate resistance-bypass / escape targets for a given target. From a deterministic keyword pass over the literature (resistance_relations — GLiREL has no resistance edge type), surfaces targets co-mentioned with the query target in resistance-context abstracts, ranked by a drugability-gap score (strong resistance evidence, low development activity). Hypothesis generator, not evidence — every row carries its source snippet.

  • mosaic_synthetic_lethal_whitespaceSynthetic-Lethal Whitespaceread-only

    Find synthetic-lethal *whitespace*: targets functionally coupled to a developed (drugged) target but themselves undeveloped. For an anchor target with chemical matter, surfaces partners coupled to it by DepMap co-essentiality, STRING protein-protein interactions and/or Reactome pathways. Returns TWO lists, deliberately not merged: - `candidates` — partners Mosaic covers, filtered to < 5 patents and no compound past phase 0. Those counts are measured, so a whitespace claim is supportable. Ranked by `whitespace_score`. **Read `clinical_absence_caveat`**: it is set when a partner carries …

  • mosaic_target_networkTarget Knowledge Graph Networkread-only

    Get the 1-hop neighborhood around a drug target. Returns the entities DIRECTLY connected to the target — compounds, diseases, pathways, patent-holding organizations, interacting proteins — as nodes and edges. This is a star centered on the target (independent 1-hop lookups), not a multi-hop graph traversal: it shows the target's immediate context, not paths that hop through intermediate entities.

  • mosaic_target_validationAssay Precedent (Target Validation)read-only

    Assay precedent for a drug target: what has been tried, in what model system. Returns literature-derived experimental precedent — genetic (CRISPR/siRNA/KO), in vivo (mouse/rat/xenograft), pharmacological (inhibitor/SAR), and clinical- trial evidence — re-classified per paper at query time. A paper may carry several methods; counts are lower bounds, not exhaustive. Papers that name the target in their title are flagged high-confidence and lead the ranked exemplars. Outcomes are NOT auto-graded: open the linked exemplar papers to read what actually happened. Also returns DepMap essentiality + A…

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    Weekly downloads
    262
    Last commit
    Oct 18, 2026 (10 days ago)
    Last release
    Oct 17, 2026 (11 days ago)
    Last package publish
    Oct 17, 2026 (11 days ago)

    From GitHub (fetched Oct 24, 2026) and the package registry.

    Details

    Registry name
    io.github.sourabhnk/mosaic-mcp
    Version
    2.2.1
    Auth
    API key
    Packages
    pypi mosaic-mcp
    License
    Apache-2.0
    Repository
    github.com/sourabhnk/mosaic-mcp
    First seen
    Oct 24, 2026
    Last checked
    Oct 24, 2026
    Source
    Official MCP Registrygithub-graphql
    Cite this page

    Mosaic Pre-Clinical Intelligence MCP server. Agent Mart. https://agentmart.dev/connectors/sourabhnk-mosaic-mcp (last updated 2026-10-24)