Agentic Target Evidence

Fetch genome-wide significant GWAS associations for a gene from EBI GWAS Catalog.

Resolve a gene symbol (including aliases/previous symbols) to its canonical HGNC record.

Fetch HPO phenotype breadth/specificity and inheritance-mode hints for a gene.

Fetch IMPC statistically significant knockout-mouse phenotype calls for a gene.

Resolve a disease name or existing ontology id to its MONDO term and cross-references.

Fetch OMIM Mendelian phenotype-gene associations for a gene (no-op if OMIM_API_KEY unset).

Resolve a journal's OpenAlex quality signal from ISSN (preferred) or title.

Count FDA-approved drugs for an indication, regardless of target gene. Target-agnostic disease-level competitive landscape (contrast with `openfda_search_drug_labels`, which is gene-keyed). Returns the approved-drug count, drug names, a few mechanism-of-action examples, and which query path matched (`phrase` / `broad` / `none`).

Fetch FAERS adverse event summary for a drug name. Returns total, serious, and death report counts plus the top 25 reactions by frequency. FAERS has significant noise — treat as signal-generating, not ground truth (underreporting, confounders, duplicate submissions).

Search FDA drug labels for drugs mentioning the gene in mechanism of action or approved for the given indication. Returns up to 20 deduplicated label records (NON_SENSITIVE, public API).

Fetch gene-disease association scores from the Open Targets Platform. gene_id must be an Ensembl ID (e.g. ENSG00000012048 for BRCA1). disease_id must be an EFO ID (e.g. EFO_0000305 for breast carcinoma).

Fetch eQTL/pQTL ↔ GWAS colocalisations for a gene (OT Genetics). Returns molecular QTL signals for this gene that colocalize with GWAS loci (posterior H4 >= h4_threshold). gene_id must be an Ensembl ID.

Fetch known drugs targeting a gene from the Open Targets Platform. Returns drug name, type, clinical phase, approval status, mechanism of action, and the indication each drug is being developed for. gene_id must be an Ensembl ID.

Fetch GWAS Locus-to-Gene (L2G) evidence for a gene-disease pair (OT Genetics). Returns GWAS credible sets where this gene is prioritized as the likely causal gene for the given disease. gene_id must be an Ensembl ID; disease_id must be an EFO/MONDO ontology ID.

Fetch mouse knock-out phenotypes for a gene from Open Targets (MGI/IMPC). Returns phenotypic consequences of disrupting the mouse orthologue, establishing biological plausibility and early safety signals. gene_id must be an Ensembl ID.

Fetch safety liabilities for a gene from the Open Targets Platform. Returns curated adverse event and toxicity signals (hepatotoxicity, cardiotoxicity, nephrotoxicity, etc.) from FDA FAERS and toxicology databases. gene_id must be an Ensembl ID.

Fetch tractability evidence for a gene from the Open Targets Platform. Returns small-molecule and antibody tractability flags plus any other modalities (PROTAC, oligonucleotide, etc.).

Resolve a disease name (e.g. 'breast cancer') to its EFO/MONDO ID via Open Targets search.

Resolve a gene symbol (e.g. BRCA1) to its Ensembl ID via Open Targets search.

Fetch Orphanet rare-disease gene-disease associations for a gene.

Fetch Orphanet disease-prevalence records for a set of OrphaCodes.

Fetch Project Score (Sanger) CRISPR fitness/dependency data for a gene.

Fetch the abstract and metadata for a single PubMed article.

Return full-text availability info via PubMed Central. Returns None if the article is not in PMC.

Search PubMed using the NCBI E-utilities API. Respects the NCBI free-tier rate limit (3 req/s). Pass an NCBI_API_KEY env var to raise the limit to 10 req/s.

Resolve a journal's SJR score and quartile from ISSN (preferred) or title.

Fetch SPOKE Anatomy-Gene expression edges for a gene symbol.

Fetch SPOKE Disease-ASSOCIATES-Gene edges for a gene symbol.

Fetch TTD target development-status + mapped drugs for a gene (no-op if TTD_ENABLED unset).

Fetch the reviewed human UniProt protein profile (class, location, ChEMBL xref).

Search PatentsView for patents referencing the gene and disease. All results are classified NON_SENSITIVE (patent data is public).